Getting the right tools. It is so important. Certainly, once you have them, suddenly they are critical. Like having a great knife if you are a chef. For myself it comes down to the right computer and the right software. And I think I finally found all the right tools. Thank you technology!
I just got my brand new HP TM2 2050 tablet computer

and though there have been, and continue to be a couple of quirks, namely when I shut down in tablet position it stays there when I relaunch - so that at first, everything is upside down. That is easily fixed by putting the tablet back in tablet position and then back in computer position again. Another quirk that I haven't found an easy fix for is the pen sometimes goes in the opposite direction than the way I am moving - I found just closing and opening the program resets it...but I do wish it wouldn't do that.
I would like the descriptions in the 'context' menu for tools to show up above the tool rather than below as my pen and hand block the descriptions. I hope I can find something that will adjust that.
Otherwise, it is a dream machine and everything I hoped it would be. The learning curve on the new Windows 7 is a bit of a challenge. It would have been nice if they included more tips and instructions - especially for tablet users - as some things don't work the same way in tablet position.
Now, for Manga Studio.
I purchase the EX Hybrid version, which is the full professional version good for Mac & PC and it is priced at 299.99
this link will take you to the site AND get you 10% off the price. Save 10% on Manga Studio EX 
Right out of the box this software was immediately useable and useful. The very user friendly beginner panel is right there. With a number of different tools and layer options to work with, I can create a sketch in 'blue pencil' and then when I am ready...the magic begins with inking. Now inking has thus far been my least favorite thing to do prior to getting this software. Now I think it is my favorite thing. All my lines are smoothed and perfected. The range of tools and the beautiful pressure-sensitivity I get from my pen tablet on the screen is amazing. It just looks so professional and better than when I draw with pen and paper. Editing is easier and no more smudgy pencil on my face, arms, hands etc. I may never use pencil and paper again to sketch - this program is that good. I should add that the tools will, for the most part, be identical to those you are used to in Photoshop and that alone shortens the learning curve quite a bit. The language is familiar (nodes are called vertices though).
It will provide a number of layers and options (though it will allow only 2 colours plus transparency per layer) convert photos into tone images for use in drawings, and has a 3d design element as well - which I am not at all familiar with yet. It handles full color in CMYK or RGB. It also, within the same program, does VECTOR! It is like having illustrator and photoshop in one little compact and beautiful program.
So far, I have done sketching with amazing results, imported line art I did by hand and re-inked it so that now it is MUCH better. You can set it up like a proper book with pagination, doublepage spreads, a variety of layouts for comics and manga, and add text and more to it.
This program is fully compatible with Photoshop and I expect Corel Photopaint as well, since it will import and export all layers (if selected) as a PSD or TIFF file.
I look forward to sharing with you shortly some of my new work created with my new awesome tools.